Which medication is most commonly prescribed for neuropathic pain and paresthesia?

Gabapentin is recognized as one of the most commonly prescribed medications specifically for neuropathic pain and paresthesia due to its unique mechanism of action. It works by inhibiting certain types of calcium channels on neurons, which decreases the release of excitatory neurotransmitters that can amplify pain signals. This reduction in neurotransmitter release helps to alleviate the abnormal sensations associated with neuropathic pain, making it particularly effective for conditions like diabetic neuropathy and postherpetic neuralgia.

Patients often experience significant relief from symptoms without the side effects that can accompany other classes of pain medications. Gabapentin's efficacy in managing neuropathic pain has been supported by numerous clinical studies, reinforcing its status as a first-line treatment option in these circumstances. This effectiveness in treating nerve-related pain distinguishes it from other medications listed, which either mainly address inflammatory pain (like ibuprofen) or act on opioid receptors (like oxycodone).