What are the best defenses against wound infection and sepsis?

The best defenses against wound infection and sepsis include excision and closures. Excision involves the surgical removal of dead or infected tissue, which reduces the microbial load in a wound and helps promote healing by allowing healthy tissue to regenerate. This is a critical step in preventing infection, as it removes not only potential pathogens but also necrotic tissue that can serve as a breeding ground for bacteria.

Closures involve suturing or otherwise sealing a wound, which minimizes the exposure of underlying tissues to external pathogens, thus further reducing the risk of infection. A well-closed wound promotes faster healing and creates a more favorable environment for tissue repair, decreasing the likelihood of sepsis.

While other options like debridement, drainage, and antibiotics certainly play important roles in managing wounds and preventing infection, excision and closures are fundamental components that directly address the physical state of the wound and the potential for infection by ensuring that harmful tissue is removed and that the wound is protected from further contamination.